Collodian Baby
Other names: None
OMIM: None
Inheritance: variable
Incidence: 1:100,000 (?)
Key findings:
- skin: parchment-like covering of entire skin surface that cracks before or shortly after birth and then peels off in 2-4 weeks; eversion of eyelids (ectropion) and lips (eclabium) improves as collodion membrane shed
Associated findings: may be none; depends on the skin type causing the collodion membrane
Age at first appearance: birth
Long-term course: depends on underlying cause; most individuals have lifelong lamellar ichthyosis or congenital ichthyosiform erythroderma; some shed the collodion membrane and have no skin or other sequelae; some have trichothiodystrophy, X-linked recessive, neutral lipid storage disease, or Gaucher's disease
Diagnostic tests: none
Abnormal gene: many
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